Tesamorelin

For Laboratory Research Use Only — Not for Human or Veterinary Use.

Standard (< 1,000 vials)$400/kit

Volume (1,000+ vials)$320/kit

Quantity (kits)

= 10 vials

Minimum order: 100 vials total. Mix and match across all products.

I confirm this order is for laboratory research use only.For Laboratory Research Use Only — Not for Human or Veterinary Use. By checking this box you affirm this product will not be used for human or animal administration.

Specifications

CAS Number	218949-48-5
Molecular Formula	C221H366N72O67S
Molecular Weight	5135.86 g/mol
Purity	≥98% (HPLC)
Form	Lyophilized Powder
Storage	-20°C, desiccated, protected from light
Reconstitution	Bacteriostatic water

Certificate of Analysis

Lot documentation

Every production lot is independently third-party tested. A batch-specific Certificate of Analysis — documenting HPLC purity, mass spectrometry identity confirmation, and net peptide content — is issued with every shipment. View a sample COA to see the format.

View Sample COA About our testing →

Research context

A full-length GHRH(1-44) analog carrying an N-terminal acyl group, distinguishing it from the 1-29 fragment analogs. Supplied lyophilised, with acylation verified per lot.

Structure and molecular target

Tesamorelin is a 44-residue analog of growth hormone releasing hormone bearing a trans-3-hexenoyl group on the N-terminal tyrosine. It is structurally distinct from sermorelin and the CJC-1295 series in a way that matters: those are analogs of the 1-29 fragment, whereas this is the full-length 44-residue sequence.

The N-terminal acyl group serves the same purpose the D-alanine substitution serves in modified GRF(1-29): it blocks dipeptidyl peptidase-4 from cleaving the exposed N-terminus, which is the fastest degradation route for any GHRH sequence. The two compounds solve the same problem by different chemistry, one by acylation and one by stereochemical substitution. Its target is the GHRH receptor, a class B G-protein-coupled receptor.

Findings in the published research literature

In-vitro characterisation uses cAMP accumulation assays in cells expressing the GHRH receptor, with pituitary cell preparations for direct examination of releasing activity. Comparative stability work against the unmodified sequence is a substantial part of the reported literature, since resistance to N-terminal cleavage rather than altered receptor affinity is the design objective.

The full-length backbone is the other point of comparison. Residues beyond position 29 are not required for receptor activation, which is why the shorter fragment analogs are active at all, but the reported work examines whether the additional sequence affects receptor residence and conformational stability in ways the truncated analogs do not.

Analytical verification

At 44 residues this is a long solid-phase synthesis and deletion sequences are correspondingly the dominant impurity class. On a molecule this size a single missing residue is a small relative mass shift that chromatography resolves more reliably than a routine mass check, so reversed-phase HPLC purity carries more weight here than on shorter sequences.

The N-terminal acylation requires separate confirmation, since an unacylated lot is the native sequence rather than this compound and carries the dipeptidyl peptidase-4 liability the acyl group exists to remove. The sequence retains asparagine and methionine residues that the modified GRF analogs substituted away, so deamidation and oxidation products are both worth reviewing on incoming documentation.

Handling and storage

Solubility	Soluble in aqueous buffer at neutral pH.
Reconstitution	Add diluent against the vial wall and swirl gently. The N-terminal acyl group gives this sequence more surface activity than an unmodified peptide, so avoid vigorous agitation.
Storage	Lyophilised powder at -20C, desiccated and protected from light. Reconstituted solution at 2-8C.
Stability	Less chemically robust in solution than the modified GRF(1-29) analogs, which had their deamidation- and oxidation-prone residues engineered out. Prepare fresh where possible.