GHRP-2

For Laboratory Research Use Only — Not for Human or Veterinary Use.

Standard (< 1,000 vials)$150/kit

Volume (1,000+ vials)$110/kit

Quantity (kits)

= 10 vials

Minimum order: 100 vials total. Mix and match across all products.

I confirm this order is for laboratory research use only.For Laboratory Research Use Only — Not for Human or Veterinary Use. By checking this box you affirm this product will not be used for human or animal administration.

Specifications

CAS Number	158861-67-7
Molecular Formula	C45H55N9O6
Molecular Weight	817.97 g/mol
Purity	≥98% (HPLC)
Form	Lyophilized Powder
Storage	-20°C, desiccated, protected from light
Reconstitution	Bacteriostatic water

Certificate of Analysis

Lot documentation

Every production lot is independently third-party tested. A batch-specific Certificate of Analysis — documenting HPLC purity, mass spectrometry identity confirmation, and net peptide content — is issued with every shipment. View a sample COA to see the format.

View Sample COA About our testing →

Research context

A hexapeptide ghrelin receptor agonist, less selective than ipamorelin by design and by reported profile. Supplied lyophilised, with C-terminal amidation verified per lot.

Structure and molecular target

GHRP-2, also known by the international nonproprietary name pralmorelin, is a hexapeptide with the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys and a C-terminal primary amide. Three of its six residues are D-configured or unnatural, which is what allows so short a sequence to resist peptidase cleavage.

It agonises the growth hormone secretagogue receptor 1a, the same target as ghrelin and ipamorelin. Unlike the GHRH receptor engaged by sermorelin and the CJC-1295 series, this receptor signals principally through Gq, so the appropriate in-vitro readouts are calcium mobilisation and inositol phosphate accumulation rather than cAMP.

Findings in the published research literature

The comparative literature between this compound and ipamorelin is the most informative body of work for placing it. Both engage the same receptor, but GHRP-2 is reported in animal models to elevate adrenocorticotropic hormone, cortisol and prolactin alongside its primary effect, whereas ipamorelin was specifically characterised as producing markedly less of that cross-activity at comparable receptor occupancy.

That difference is the reason both compounds remain in use as research articles rather than one superseding the other: a study examining secretagogue signalling in isolation and a study examining the broader endocrine response require different tools. Pituitary cell preparations are the standard ex-vivo system for both.

Analytical verification

Reversed-phase HPLC establishes purity and mass spectrometry confirms identity, reported per lot on the Certificate of Analysis. As with any D-configured sequence, epimerisation is the impurity that mass spectrometry cannot see: a D-to-L inversion at any of the three affected positions yields a diastereomer of identical mass, separable only chromatographically.

C-terminal amidation requires separate confirmation, since the free-acid by-product differs by one dalton and is substantially less active at the receptor. The single tryptophan is an oxidation liability, adding 16 daltons and typically resolving as a distinct peak, and its level on incoming documentation reflects storage and handling history as much as synthesis quality.

Handling and storage

Solubility	Freely soluble in water and neutral aqueous buffer.
Reconstitution	Dissolves rapidly with gentle swirling.
Storage	Lyophilised powder at -20C, desiccated and protected from light. Light protection is not a formality here: the tryptophan residue is photosensitive.
Stability	Tryptophan oxidation is the dominant degradation route. Minimise headspace air and avoid prolonged storage in solution or under illumination.